The second round of matches in the 2025/26 Champions League takes centre stage this week.
The standout game is on Wednesday evening as reigning champions Paris Saint-Germain head to Spain to face La Liga leaders Barcelona.
Read on as we look at the latest Champions League betting, before previewing what promises to be an action-packed line-up of fixtures.
Champions League 2025/26 – Betting
Matchday 1 triggered a betting frenzy across Europe, and the latest batch of league phase fixtures are guaranteed to generate similar levels of activity.
Several of the casinos not on Gamban also have associated sportsbooks which offer an extensive range of markets on the Champions League.
For players more familiar with popular games such as blackjack and roulette, the competition offers the chance to boost their bankroll if they make the right selections. Here are the latest outright odds:
- Liverpool – 6/1
- Arsenal – 6/1
- Barcelona – 6/1
- Paris Saint-Germain – 6/1
- Real Madrid – 8/1
- Manchester City – 9/1
- Bayern Munich – 10/1
- Chelsea – 16/1
- Inter Milan – 22/1
- Tottenham Hotspur – 25/1
- Napoli – 28/1
- Newcastle United – 33/1
- Atletico Madrid – 40/1
- Juventus – 40/1
- Borussia Dortmund – 66/1
- Bayer Leverkusen – 66/1
- Atalanta – 66/1
- Eintracht Frankfurt – 80/1
- Athletic Club – 100/1
- Monaco – 100/1
- Villarreal – 125/1
- Marseille – 125/1
- Sporting CP – 150/1
- Union St Gilloise – 200/1
- Club Brugge – 200/1
- Benfica – 200/1
- PSV Eindhoven – 200/1
- Ajax – 250/1
- Galatasaray – 250/1
- Olympiacos – 250/1
- FC Copenhagen – 250/1
- Bodo/Glimt – 500/1
- Paphos – 500/1
- Slavia Prague – 1000/1
- Qarabag – 1000/1
- Kairat Almaty – 1500/1
Champions League 2025/26 – Matchday 2 Fixtures & Preview
Tuesday, September 30
- Atalanta vs Club Brugge
- Kairat Almaty vs Real Madrid
- Atletico Madrid vs Eintracht Frankfurt
- Chelsea vs Benfica
- Inter Milan vs Slavia Prague
- Bodo/Glimt vs Tottenham Hotspur
- Galatasaray vs Liverpool
- Marseille vs Ajax
- Pafos vs Bayern Munich
Wednesday, October 1
- Qarabag vs FC Copenhagen
- Union Saint-Gilloise vs Newcastle United
- Arsenal vs Olympiacos
- Monaco vs Manchester City
- Bayer Leverkusen vs PSV Eindhoven
- Borussia Dortmund vs Athletic Club
- Barcelona vs Paris Saint-Germain
- Napoli vs Sporting CP
- Villarreal vs Juventus
Several fancied teams hit the road on Matchday 2 and will be eager to avoid slipping up against lower-ranked opponents.
They include La Liga giants Real Madrid, who visit tournament outsiders Kairat Almaty in one of the two early games on Tuesday evening.
Tottenham Hotspur also face a tricky test against Bodo/Glimt, while Liverpool would be well advised to avoid any complacency at Galatasaray.
The headline fixture is at Stamford Bridge, as Chelsea go head-to-head with Benfica. Former Blues manager Jose Mourinho is now in charge of the Portuguese club.
Mourinho will be eager to upset the odds against his former employers, and Benfica could be a good bet to take at least a point from the game.
The mouth-watering clash between Barcelona and PSG on Wednesday night is expected to garner a massive worldwide television audience.
Both teams kicked off their respective Champions League campaigns with victories and will be eager to make an early statement in the competition.
Manchester City will bid to follow up their 2-0 home victory over Napoli when they visit Ligue 1 side Monaco in their second outing.
Pep Guardiola’s side demolished Burnley in the Premier League over the weekend and will be keen to continue their good form at the Stade Louis II.
Newcastle United face a tricky test in Belgium against Union Saint-Gilloise, while Juventus travel to Spain to face Villarreal.
Arsenal are a banker bet to pick up three points against Olympiacos, and odds of 20/21 to ‘win to nil’ should deliver a winning return to punters who take the plunge.
